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KMID : 0391520120200030196
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Journal of the Korean Child Neurology Society
2012 Volume.20 No. 3 p.196 ~ p.200
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Detection of Human Herpesvirus-6 (HHV-6) in Cerebrospinal Fluid of a Patient with Fatal Status Epilepticus
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Cho Sung-Min
Song Jung-Sook
Kang Eun-Kyeong
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Abstract
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Human herpesvirus-6 (HHV-6) often causes mild illnesses, but is rarely associated with encephalitis or other fatal neurological conditions. We report a girl who died of a intractable status epilepticus from HHV-6. A 14-month-old girl presented with focal motor seizures in right extremities evolving to generalized convulsive status epilepticus. She had a history of mild diarrhea for 4 days and high fever for 2 days. Although she was treated with lorazepam, phenytoin, phenobarbital, and continuous midazolam infusion, generalized seizures continued for 3 hours after arrival. She became seizure free, but remained unconscious and ended up to death at the 44 days of hospitalization. The CSF HHV-6 DNA PCR turned out to be positive.
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KEYWORD
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Human herpesvirus-6, Encephalitis, Status epilepticus, Brain death
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